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KMID : 1150720140030040211
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Integrative Medicine Research
2014 Volume.3 No. 4 p.211 ~ p.216
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Integrative approach in the era of failing drug discovery and development
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Earm Kee-Hyun
Earm Yung-E
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Abstract
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The productivity decline in drug discovery and development is mainly caused by two factors; higher regulatory hurdles and low-hanging fruits being all picked. In addition, the recent target-based approach is thought to be increasing the price of innovation. Although target-based approach had many successes, a postreductionism method, which is systems biology, is on the rise. In this review, we discuss the foundations of two distinct approaches in finding a new drug.
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KEYWORD
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drug development, integrative, reductionism, systems biology, target-based approach
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